Changing patterns of referral into a family history clinic and detection of ovarian cancer: a retrospective 10-year review

Abstract

This study examines whether a change in the criteria for genetic testing for ovarian cancer risk changed the nature of referrals into our Familial Cancer service. This is a retrospective review of 273 women who underwent risk reducing surgery (RRS). The primary outcome was to establish whether there was an increase in women having RRS with a confirmed genetic mutation. Secondary outcomes included the incidence of occult cancer and of subsequent primary peritoneal cancer. The results showed an increase in women being offered RRS based on genetic diagnosis; 91% versus 32% before the criteria change. Four occult malignancies (1.5%) and two peritoneal cancers (0.7%) were noted.

We have demonstrated a change in the nature of referrals to the familial cancer service from perceived risk to genetic diagnosis. We can now counsel women more accurately. With a defined risk we are enabling them to make an informed decision regarding risk reduction.

Keywords:

• Ovarian cancer
• familial cancer
• BRCA
• Lynch
• risk reducing surgery

Ethical approval

Registration of this study was deemed unnecessary due to the nature of the study.

Disclosure statement

No potential conflict of interest was reported by the author(s).