Efficacy of combined ethinyloestradiol (0.035 mg) and cyproterone acetate (2 mg) in acne and hirsutism in women with polycystic ovary syndrome

Abstract

Summary The effects of an oral contraceptive containing ethinyloestradiol and cyproterone acetate on acne and hirsutism were studied in 82 women with polycystic ovary syndrome. The contraceptive was administered for 48 consecutive cycles. Hormone and ultrasound evaluations were carried out at baseline and after 48 treatment cycles. Acne and hirsutism were evaluated after 18, 24, 36 and 48 treatment cycles. Acne resolved in all patients within 24 treatment cycles. Mild and moderate hirsutism resolved within 48 treatment cycles. Severe hirsutism persisted although it changed to mild or moderate in most of the affected women.