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Abstract
This paper discusses some issues in chronic disease epidemiology of interest to the genetic epidemiologist and presents a useful technique available to address these problems. This technique employs information from families of adult twins. It allows for an assessment of genetic and environmental components of variation of quantitative traits. We have developed a method for compiling a registry of adult twins, and this may be of use to others. Major problems that must be considered in any research with this technique are the representativeness of the cohort and the generalizability of results.