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Abstract
Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent and deadly cancers worldwide, especially in Eastern Asia. As a potential endocrine-disrupting chemical (EDC), perfluorooctane sulfonate (PFOS) can mimic estrogen, disturb the estrogen signals, and then cause various diseases. Although ESCC can be directly exposed to PFOS during food digestion, the effects and mechanisms of PFOS on the development of ESCC are still not well illustrated. This study showed that PFOS can promote the migration and invasion of ESCC cells. Further, PFOS treatment can increase the expression of matrix metalloproteinase-2 (MMP-2) and MMP-9, while decreasing the expression of E-Cadherin (E-Cad). Zeb1, an important transcription factor for cell motility, was essential for PFOS induced migration and invasion of ESCC cells. PFOS can increase the expression of Zeb1 via upregulation of its transcription and proteins stability. A-kinase interacting protein 1 (AKIP1) and ataxia-telangiectasia mutated (ATM) were responsible for PFOS induced transcription and proteins stability of Zeb1 in ESCC cells, respectively. Collectively, our data indicated that environmental exposure and body accumulation of PFOS might be an important risk factor for ESCC progression.
Ethical approval
No animal or human-related experiment. All authors give the consent for the publishing of this study.
Author contributions
Conception and design: Yaqing Liu, Jian Li, Hui Ding, Chunjin Xu;
Acquisition of data: Yaqing Liu, Dahe Ge, Juntao Wang, Chunjin Xu;
Analysis and interpretation of data: Hui Ding, Dahe Ge, Juntao Wang, Chunjin Xu;
Writing, review, and/or revision of the manuscript: Yaqing Liu, Jian Li, Chunjin Xu.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data availability statement
All data and material are available.