Liquid Chromatographic Resolution of Enantiomers on Chiral Amide Bonded-Silica Gel Normal Phase Separation of Racemic α-Amino Acid Derivatives by N-Acetyl-L-valyl-aminopropyl-silanized Silica (AVA) Phase

Abstract

A new optically active stationary phase obtained by grafting N-acetyl-L-valine with 3-aminopropylsilanized silica was developed. The high-efficiency chiral column was prepared by slurry packing procedure. Direct resolution of the racemates of α-amino acid derivatives was accomplished by using normal phase liquid chromatography.