Chromatographic Study of Interactions Between N,N-Disubstituted Polyacrylamides and Phenols Comparison with Infrared Spectroscopic Data

Abstract

The determination of retention data by liquid chromatography (LC), for a series of p-substituted phenols on various packings formed with N,N-disubstituted polyacrylamides, permits characterization of polymer-solute interactions which govern the partition of phenols between the mobile and the stationary phases. The partition coefficient, K_j, changes with the nature of the polymer, and increases with the phenolic acidity. We propose a linear relationship between K_j and the complexation constant of phenol-amide hydrogen bond, determined by infrared spectroscopy. This relationship has been qualitatively checked.