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Abstract
A method was developed to identify radiolabeled DES and DES metabolites in biological fluids and tissues. After a rapid initial clean-up step, the biological samples were analyzed with a single-column, reversed-phase, highpressure liquid chromatography system. The parent compound and metabolites were simultaneously resolved and tentatively identified by comparing their retention times to those of known standards. Positive identification of some metabolites was achieved by field-desorption and capillary-column mass-spectrometric analysis. The method was found to be rapid and reproducible, and sample recovery was >80%.