Abstract
Liquid chromatography and electrochemistry have been combined (LCEC) to form a new analytical approach with unique capabilities. While LCEC is now well established for oxidizable substances, its use for determination of reducible compounds is just beginning to develop. The electrochemistry of easily reducible functional groups (electrophores) is briefly discussed. Factors which influence the performance of reductive mode detection are reviewed, including mobile phase composition, electrode material, voltage waveform, and dissolved oxygen. Recent applications of reductive mode LCEC are presented.