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Abstract
A rapid and effective high-pressure liquid chromatographic method has been developed for the quantitative determination of dexamethasone 21 acetate in pharmaceutical formulations. Sample preparation employs a simple extraction procedure and analysis is carried out on a reversephase chromatographic system using a LiChrosorb RP 18 column and a water-acetonitrile as mobile phase. The extraction procedure gives quantitative recovery and chromatographic results show that drug levels of as 0.1 ppm can be conveniently analyzed without significant background interferences.