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Abstract
A high-performance liquid chromatographic (HPLC) method is described for the determination of an analog of the hormone LH-RH in lyophilized vials at the low parts-per-million level. The peptide (Schally analog) is quantitatively recovered from the glass lyophilization vials after reconstitution with mobile phase. The peptide solution is eluted on a reversed-phase, C18 column and monitored with ultraviolet (UV) detection at 220 nm. The chromatography resolves Schally analog from a number of synthetic impurities and decomposition products.