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Original Articles

Purification of Radio-Iodinated Cholecystokinin Peptides by Reverse Phase HPLC

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Pages 757-766 | Published online: 05 Dec 2006
 

Abstract

The purification of the iodinated tracers of CCK peptides using Sphadex G5O chromatography does not allow for a good separation between non-modified peptides and labelled peptides. We present, in this paper a simple and rapid purification method using reverse phase HPLC with a C-18 column for four of these tracers. The biological characteristics of the molecules obtained demonstrate their strong specific radioactivity and their high degree of purity.

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