Effect of Substituents on the Retention in HPLC Chromatography of Strychnine Derivatives

George M. Iskander Dept. of Chemistry, University of Khartoum, P.O.Box, 321, Khartoum, SUDAN

J. Strombom Dept. of Chemistry, University of Khartoum, P.O.Box, 321, Khartoum, SUDAN; Biomedicum center, U.S. of Uppsala, Sweden

A. M. Satti Dept. of Chemistry, University of Khartoum, P.O.Box, 321, Khartoum, SUDAN

Abstract

The capacity factork, relative retentions α_SP and log α_SP values measured on μPorasil columns for 33 strychnine derivatives using CHCl₃:MeOH (containing ca 2% NH₄OH) (93:7) as eluent in normal-phase chromatography. The results allow for the estimation of the effect of various substituents on the retention of these alkaloids.

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Effect of Substituents on the Retention in HPLC Chromatography of Strychnine Derivatives

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Effect of Substituents on the Retention in HPLC Chromatography of Strychnine Derivatives

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