Rapid TLC Separation of Some Closely Related Benzothiazoles

Abstract

The thiazole heterocylces have found several uses in biology, medicine and industry. In 1935, William and Coworker¹ found the existence of thiazole moeity in vitamin B₁ (Thiamine) and several of its derivatives are well know for their chemotherapeutic properties for combating bacterial infections². Amongst its other medicinal applications are the use of 6-aminobenzothiazoles as antitubercular reagents and local anaesthetics. The other uses to which this class of compounds have been put are as a rubber vulcanization accelerator³, photographic sensitizer⁴ and fungicidal⁵ etc.