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Abstract
A method has been devised for the measurement of the anti-hypertensive drug, captopril in physiological fluids. The drug is separated by chromatography on an ODS-column using a pH2 phosphate buffer/methanol (65:35) eluant and detected at a mercury electrochemical cell maintained at +0.07V v Ag/AgCl. The maximum sensitivity is greater than lpmol injected onto the column. The application of the methodology to acid deproteinated plasma and urine from patients receiving captopril has oeen demonstrated.