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A rapid and specific high-pressure liquid chromatography method for determination of clonazepam in human plasma is described.
The analysis is linear for concentrations ranging from 5 to 100 ng. ml-1 plasma for clonazepam.
The method is applicable to quantitation of clonazepam in human plasma of subjects receiving 0.05 at 0.20 mg.kg-1 orally, with satisfactory accuracy and precision.
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