17
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

TLC Separation of Barbiturates on Impregnated Plates

&
Pages 1265-1278 | Published online: 05 Dec 2006
 

Abstract

Barbiturates are of immense physiological importance and because of their adverse reactions leading even to death by poisoning, separation and identification of barbiturates in trace amounts is of great importance. In this work impregnation technique has been employed for working out better separation scheme for barbiturates on TLC plates. The different barbiturates studied were - phenobarbital, barbituric acid, 1:3 dimethyl barbituric acid, disodium barbitone, diethyl barbituric acid, thio barbituric acid and pentobarbital. All these seven barbiturates are satisfactory separated on 2% copper sulphate as well as 2% ethylenadiamine impregnated plates by using the solvent system benzene-netnanol (40:3) and benzene-acetone (40:12) respectively. The correlation between chromatographic behaviour and the weak interaction between the ethylenédi-anine and different barbiturates due to hydrogen bonding has been attempted.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.