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Abstract
Barbiturates are of immense physiological importance and because of their adverse reactions leading even to death by poisoning, separation and identification of barbiturates in trace amounts is of great importance. In this work impregnation technique has been employed for working out better separation scheme for barbiturates on TLC plates. The different barbiturates studied were - phenobarbital, barbituric acid, 1:3 dimethyl barbituric acid, disodium barbitone, diethyl barbituric acid, thio barbituric acid and pentobarbital. All these seven barbiturates are satisfactory separated on 2% copper sulphate as well as 2% ethylenadiamine impregnated plates by using the solvent system benzene-netnanol (40:3) and benzene-acetone (40:12) respectively. The correlation between chromatographic behaviour and the weak interaction between the ethylenédi-anine and different barbiturates due to hydrogen bonding has been attempted.