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Abstract
A specific, sensitive high performance liquid Chromatographie method for ethiofos [S-2-(3-aminopropylamino)ethyl phosphorothioate, WR 2721, I] in plasma is described. The detection limit is 0.05 (μg/mL (0.23 (μM). Application of the method to the development of pharma-cokinetic parameters following IV administration of the drug to beagle dogs is demonstrated. Presented are pharmacokinetics of unchanged drug in plasma on 10-min constant-rate infusion of 150 mg/kg to two dogs, two studies in each dog. Following the cessation of drug infusion the plasma concentration versus time profile was best described by a two-compartment pharmacokinetic model. Mean pharmacokinetic parameters were: terminal elimination half-life=16.0 min, volume of central compartment=120 mL/kg and clearance=11.0 mL/min/kg.