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Abstract
A method is described for the rapid detection and measurement of γ-aminobutyric acid (GABA) in crude extracts of mouse brain. This study includes optimisation of the pre-column derivatization of GABA by o-phthalaldehyde in the presence of ethylmercaptan as well as of the chromatographic and electrochemical conditions. The GABA levels have been measured in the hypothalamus and hippocampus of control mice and mice treated with three compounds known for their activity on brain GABA levels.