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Abstract
The growth of high performance liquid chromatography (HPLC) has significantly aided the work of the clinical pharmacokinetics laboratory. Because of its precision, sensitivity, selectivity and flexibility many analytical problems can be solved with the purchase of one instrument. We illustrate how HPLC can function in Therapeutic Drug Monitoring (TDM), large scale pharmacokinetic studies and address clinical and pharmacological problems. We also provide a condensed summary of conditions for three assays of particular value to the Research Pharmacokinetics Laboratory; for antipyrine, indocyanine green (ICG) and propranolol.