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Abstract
The reported reverse-phase HPLC method for the determination of propantheline bromide, xanthanoic acid, xanthone, and 9-hydroxy-propantheline bromide in tablets is fast, sensitive, specific, accurate and reporoducible. Methyl xanthanoate is used as internal standard. The total elution time is 6 min. The method is stability-indicating since it can determine the degradation products. The column utilized was suplecosil LC-8 (5 micron), 250 mm × 4.6 mm i.d. The mobile phase was 0.03 M solution of ammonium acetate in acetonitrile: water: THF (60:38:2); the pH was adjusted to 4.5 with acetic acid, the detection was at 254 nm. A wavelength of 248 nm was used to quantitate xanthanoic acid and the flow rate was 1.5 mL/min. The proposed HPLC method was verified for linearity, accuracy, precision, and applicability.