Liquid Chromatographic Separation of the Enantiomers of Chiral Secondary Alcohols as Their α-Naphthyl Urethane Derivatives

Abstract

The enantiomers of α-naphthyl urethane derivatives of a wide variety of chiral secondary alcohols are separable by liquid chromatography on a chiral stationary phase derived from a conformationally restricted β-amino acid. In many instances separation factors are sufficiently great (1.5–6.5) to enable preparative separations to be effected.