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Abstract
The interactions of adenine with 13 amino acids were studied by charge-transfer chromatography, using distilled water as eluent. The strength of each interaction was calculated from the linear dependence of the lipophilicity of adenine on the amino acid concentration. Stepwise regression analysis proved that the strength of interaction is influenced only by the lipophilicity of the amino acid side-chain and the pK value of the second carboxyl group. This finding indicates that the amino acid side-chain is directed towards the adenine, and the polar head group towards the water. The character of the interaction can be hydrophobic or hydrophilic, depending on the polarity of the amino acid sidechain.