Separation of R(+)-and S(-)-Benzyl-3-Tetrahydrofuroates Using Two Different Chiral Columns

H. Stampfli Du Pont Pharmaceuticals Medical Products Department Metabolism, and Pharmacokinetics Section Stine-Haskell Research Center, P. O. Box 30, Elkton Road Newark, Delaware, 19714

G. Patil Du Pont Pharmaceuticals Medical Products, Department Experimental Station, Wilmington, Delaware, 19899

R. Sato Du Pont Pharmaceuticals Medical Products, Department Experimental Station, Wilmington, Delaware, 19899

C. Y. Quon Du Pont Pharmaceuticals Medical Products Department Metabolism, and Pharmacokinetics Section Stine-Haskell Research Center, P. O. Box 30, Elkton Road Newark, Delaware, 19714

Abstract

A chiral separation of N(+)-and S(-)-benzyl-3-tetrahydrofuroate (I) and p-nitrobenzyl-3-tetrahydrofuroate (II) using a Chiralcel OB^© (cellulose tribenzoate) column with a hexane/2-propanol (60:40 v/v) mobile phase is described. Enantiomeric purity of R(+)-I was evaluated using the same chromatographic conditions. I was also separated using a Chiralspher^© (polyamides bonded to silica gel) column with an ethanol/distilled water (50:50 v/v) mobile phase.

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Separation of R(+)-and S(-)-Benzyl-3-Tetrahydrofuroates Using Two Different Chiral Columns

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Separation of R(+)-and S(-)-Benzyl-3-Tetrahydrofuroates Using Two Different Chiral Columns

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