22
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

A New Quaternary Mobile Phase System for Optimization of TLC Separations of Alkaloids Using Mixture Designs and Response Surface Modelling

, , , , &
Pages 3213-3239 | Published online: 23 Oct 2006
 

Abstract

A new combination of four organic solvents is proposed for the optimization of TLC separations of basic drugs and alkaloids. The solvents are diethylamine (DEA), methanol (MeOH), chloroform (CHCl3) and ethylacetate (EtAc). They were selected from a collection of ten solvents used in Normal Phase TLC mobile phases recommended for the separation of alkaloids and basic drugs in the literature. The selection was based on the classification of solvents according to selectivity and solubility parameters. Excluded were apolar and weak solvents that show no selective (polar) properties and are used only for the adjustment of the solvent strength. Polar solvents from different selectivity groups were selected to combine as many as possible selective effects in one solvent system. The final choice was made considering the displacement theory for Liquid Solid Chromatography.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.