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Original Articles

Determination of Cefpirome in Human Plasma by High-Performance Liquid Chromatography

Pages 193-200 | Published online: 23 Oct 2006
 

Abstract

Cefpirome is an investigational third-generation cephalosporin, which appears promising for the treatment of various pediatric infections. A high performance liquid chromatographic method was developed to measure cefpirome in small volumes of plasma for conducting pharmacokinetics studies in infants and children. the assay involved precipitation of plasma proteins with acetonitrile, using cefaclor as an internal standard. Chromatographic separation was accomplished using a reverse-phase

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