BROMOCRIPTINE FOR INFERTILE MALES WITH MILD HYPERPROLACTINEMIA: HORMONAL AND SPERMATOGENIC EFFECTS

K. Nishimura Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan

K. Matsumiya Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan

N. Tsuboniwa Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan

M. Yamanaka Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan

M. Koga Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan; Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan

H. Miura Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan; Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan

A. Tsujimura Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan; Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan

K. Uchida Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan; Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan

N. Kondoh Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan; Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan

M. Kitamura Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan; Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan

A. Okuyama Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan; Department of Urology, Osaka University Medical School and Osaka Central Hospital, Osaka, Japan

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Abstract

To clarify the influence of hyperprolactinemia on spermatogenesis and steroidogenesis in infertile male patients, the serum prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, and estradiol concentrations were and the effect of bromocriptine treatment on spermatogenesis was examined. A total of 1234 patients were evaluated and 147 men had hyperprolactinemia. Of these, only 30 had PRL concentrations more than twice the upper limit of normal and most of them had a little excess over the upper limit. For 10 of these 30, serum hormone concentrations were measured and semen was analyzed before and after bromocriptine administration. No relationship between the PRL and other hormone concentrations was found. No changes were noted in the LH, FSH, testosterone, or estradiol concentrations, or in the sperm density and motility after treatment. The mean PRL decreased from 26.5 +/- 4.5 to 1.4 +/- 1.8 ng/mL. In infertile men who are mildly hyperprolactinemic, bromocriptine administration does not improve semen analysis, although it does normalize the PRL.

Keywords

Bromocriptine;Hyperprolactinemia;Infertility;Semen;Spermatogenesis

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BROMOCRIPTINE FOR INFERTILE MALES WITH MILD HYPERPROLACTINEMIA: HORMONAL AND SPERMATOGENIC EFFECTS

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BROMOCRIPTINE FOR INFERTILE MALES WITH MILD HYPERPROLACTINEMIA: HORMONAL AND SPERMATOGENIC EFFECTS

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