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Literature data on water-solvent partition coefficients have been used to obtain Abraham descriptors for 8-hydroxyquinoline and a large number of its derivatives. From these descriptors and known equations for water-solvent partitions, it is possible to predict partition coefficients for 40 derivatives of 8-hydroxyquinoline in 51 water-solvent systems with an error of about 0.05 log units. The method is entirely transparent and requires no more than simple arithmetic to implement.
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