Smart combination of β-cyclodextrin polymer-conjugated magnetic nanosorbent for potential adsorption of deoxyribonucleic acid

ABSTRACT

We reported the synthesis and characterization of Fe₃O₄ magnetic nanoparticles modified β-cyclodextrin polymer (MNP@βCD-TDI) for the adsorption of deoxyribonucleic acid (DNA). The synthesized MNP@βCD-TDI was characterized by Fourier Transform Infra-Red spectroscopy and Vibrating Sample Magnetometer. Experiments were performed in a batch mode and parameters that affected the DNA adsorption were investigated. An evaluation of the adsorption behavior revealed that Freundlich model and pseudo-second-order fit the equilibrium data. The adsorption efficiency of DNA was found to be at $70\pm 5\mathrm{\%}$ after being recycled three times. This study could be used as a general platform for future work on DNA adsorption and enrichment.

KEYWORDS:

• β-Cyclodextrin
• adsorption
• magnetic nanoparticles
• biomedical application
• inclusion complex

Acknowledgements

The authors would like to express their gratitude to Research University Grant, Universiti Sains Malaysia (RUI: 1001/CIPPT/811322) and Fundamental Research Grant Scheme, Ministry of Higher Education (MOHE), Malaysia (FRGS: 203/CIPPT/6711557) for their financial support.

Conflict of interest

The authors have declared no conflict of interest.

Additional information

Funding

This work was financially supported by the Research University Grant, Universiti Sains Malaysia [RUI: 1001/CIPPT/811322];Fundamental Research Grant Scheme, Ministry of Higher Education (MOHE), Malaysia [FRGS: 203/CIPPT/6711557].