Ag-catalyzed azide-alkyne cycloaddition: copper free approaches for synthesis of 1,4-disubstituted 1,2,3-triazoles

ABSTRACT

This review mainly focuses on purely Ag-catalyzed 1,3-dipolar azide-alkyne cycloaddition (AgAAC) so called click reaction to synthesize 1,4-regioisomers of 1,2,3-triazoles. The most established catalyst Cu (I) developed by Fokin–Sharpless and Meldal group in 2002 for AAC reaction have been further extended to different other transition metal catalysts because of certain limitations of CuAAC methods. Among different transition metal catalyzed methods, AgAAC is the most studied one having same electronic configuration, d¹⁰ (AgI) with that of CuI and shows high catalytic performance.

KEYWORDS:

• AgAAC
• diverse substrates
• no-copper
• review
• room temperature

Additional information

Funding

We are thankful to DST, New Delhi, India for the research grant [No. EMR/2016/002345]. We gratefully acknowledge the Department of Science and Technology for financial assistance under DST-FIST program and UGC, New Delhi for Special Assistance Programme (UGC-SAP) to the Department of Chemistry, Dibrugarh University.