A New Skewed Link Model for Dichotomous Quantal Response Data

Abstract

The logit, probit, and student t-links are widely used in modeling dichotomous quantal response data. Most of the commonly used link functions are symmetric, except the complementary log-log link. However, in some applications the overall fit can be significantly improved by the use of an asymmetric link. In this article we propose a new skewed link model for analyzing binary response data with covariates. Introducing a skewed distribution for the underlying latent variable, we develop a class of asymmetric link models for binary response data. Using a Bayesian approach, we first characterize the propriety of the posterior distributions using standard improper priors. We further propose informative priors using historical data from a similar previous study. We examine the proposed method through a large-scale simulation study and use data from a prostate cancer study to demonstrate the use of historical data in Bayesian model fitting and comparison of skewed link models.

Key Words:

• Bayes factor
• Bayesian hierarchical model
• Informative prior
• Latent variable
• Markov chain Monte Carlo
• Posterior distribution.