Inter-Subject Analysis: A Partial Gaussian Graphical Model Approach

Abstract

Different from traditional intra-subject analysis, the goal of inter-subject analysis (ISA) is to explore the dependency structure between different subjects with the intra-subject dependency as nuisance. ISA has important applications in neuroscience to study the functional connectivity between brain regions under natural stimuli. We propose a modeling framework for ISA that is based on Gaussian graphical models, under which ISA can be converted to the problem of estimation and inference of a partial Gaussian graphical model. The main statistical challenge is that we do not impose sparsity constraints on the whole precision matrix and we only assume the inter-subject part is sparse. For estimation, we propose to estimate an alternative parameter to get around the nonsparse issue and it can achieve asymptotic consistency even if the intra-subject dependency is dense. For inference, we propose an “untangle and chord” procedure to de-bias our estimator. It is valid without the sparsity assumption on the inverse Hessian of the log-likelihood function. This inferential method is general and can be applied to many other statistical problems, thus it is of independent theoretical interest. Numerical experiments on both simulated and brain imaging data validate our methods and theory. Supplementary materials for this article are available online.

Keywords:

• fMRI data
• Gaussian graphical models
• Nuisance parameter
• Sample splitting
• Uncertainty assessment

Supplementary Materials

In the supplementary materials, we provide proofs for the theoretical results in the main text.

Notes

¹ See Appendix in the supplementary materials for a proof of this observation.

Additional information

Funding

J. Lu is supported in part by NSF1916211, NIH funding: NIH1R35CA220523-01A1, and NIH5U01CA209414-02.