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Nutrition and Cancer Volume 60, 2008 - Issue 6
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Orignal Articles

Potential Role of Lycopene in the Treatment of Hepatitis C and Prevention of Hepatocellular Carcinoma

Soley Seren Department of Medicine, Wayne State University, Detroit, Michigan, USA
,
Milton Mutchnick Department of Medicine and Division of Gastroenterology, Wayne State University, Detroit, Michigan, USA
,
Daryl Hutchinson Department of Medicine and Division of Gastroenterology, Wayne State University, Detroit, Michigan, USA
,
Ozgur Harmanci Department of Medicine, Division of Gastroenterology, Hacettepe University, Ankara, Turkey
,
Yusuf Bayraktar Department of Medicine, Division of Gastroenterology, Hacettepe University, Ankara, Turkey
,
Sean Mutchnick Department of Medicine and Division of Gastroenterology, Wayne State University, Detroit, Michigan, USA
,
Kazim Sahin Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
&
Omer Kucuk Department of Medicine and Division of Hematology and Oncology, Wayne State University, Detroit, Michigan; Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA
 show all
Pages 729-735 | Received 11 Oct 2007, Accepted 17 Jul 2008, Published online: 13 Nov 2008
 
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Abstract

Hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) are growing health problems around the world. Oxidative stress plays a significant role in the initiation and progression of hepatocellular damage and possibly in the development of HCC in HCV infected patients. In vitro, animal and clinical studies suggest that lycopene, a nonprovitamin A carotenoid and a potent antioxidant, may attenuate the liver injury and possibly prevent the development of HCC. In this article, we discuss the relationship between HCV infection and oxidative stress and review the potential role of lycopene in the treatment of HCV and prevention of HCC.

Notes

a Abbreviations are as follows: Hep3B, hepatitis 3B; HCC, hepatocellular carcinoma; LEC, Long-Evans Cinnamon.

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