![Sample our Health and Social Care journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5938/TOC-Subject-Sample-2021-Health-Social-Care.jpg"})
Abstract
Several studies have evaluated the possible association between antioxidants vitamins or selenium supplement and the risk of prostate cancer, but the evidence is still inconsistent.
We systematically searched PubMed, EMBASE, the Cochrane Library, Science Citation Index Expanded, Chinese biomedicine literature database, and bibliographies of retrieved articles up to January 2009. We included 9 randomized controlled trials with 165,056 participants; methodological quality of included trials was generally high. Meta-analysis showed that no significant effects of supplementation with β-carotene (RR 0.97, 95% CI 0.90–1.05) (3 trials), vitamin C (RR 0.98, 95% CI 0.91–1.06) (2 trials), vitamin E (RR 0.96, 95% CI 0.85–1.08) (5 trials), and selenium (RR 0.78, 95% CI 0.41–1.48) (2 trials)versus placebo on prostate cancer incidence. The mortality of prostate cancer did not differ significantly by supplement of β-carotene (RR 1.19, 95% CI 0.87 -1.65) (1 trial), vitamin C (RR 1.45, 95%CI 0.92–2.29) (1 trial), vitamin E (RR 0.85, 95%CI 0.58–1.24) (2 trials), and selenium (RR 2.98, 95% CI 0.12–73.16) (1 trial). Our findings indicate that antioxidant vitamins and selenium supplement did not reduce the incidence and mortality of prostate cancer, these data provide no support for the use of these supplements for the prevention of prostate cancer.
ACKNOWLEDGMENTS
Ke-hu Yang, Lei Jiang, Jin-hui Tian participated in the study conception and design. Nan Yao, Nong Cao, and Deng-hai Mi took part in the acquisition of data. Bin Ma and Sun-hu Yang analysised the data. All authors participated in the discussion of the results and in the writing of the paper.
No funding source was used for this analysis. We thank Ya-Li Liu, Zheng-gang Bai, Sun-Shao Liang, Jun Li, Jun Wang, Xiang-yong Hao, Hong Yin, Rui-feng Liu (Evidence-Based Medicine Center of Lanzhou University, Lanzhou, Gansu) for secretarial support. We also thank Ji-ye Peng (Library of Lanzhou University) for entering data.
