Fruit and Vegetable Consumption and Lung Cancer Risk: A Case-Control Study in Galicia, Spain

Abstract

Lung cancer has multiple risk factors and tobacco is the main one. Diet plays a role, but no clear effect has been consistently observed for different fruit and vegetable consumption. We aim to assess the association between fruit and vegetable consumption and lung cancer risk through a hospital-based case-control study in Spanish population. We recruited incident lung cancer cases in 2 Spanish hospitals from 2004 to 2008. Controls were individuals attending hospital for trivial surgery. Cases and controls were older than 30 and did not have a neoplasic history. We collected information on lifestyle with special emphases on tobacco and dietary habits. We included 371 cases and 496 controls. We found no protective effect for overall fruit consumption. For green leafy vegetables, the odds ratio (OR) was 0.92 [95% confidence interval (CI) = 0.32–2.69), and for other vegetables the OR was 0.77 (95% CI = 0.40–1.48) for the categories compared. We observed a reduced risk for broccoli and pumpkin intake. Although fruit consumption does not seem to be associated with a lower lung cancer risk, only the frequent consumption of specific green leafy vegetables and other vegetables might be associated with a reduced risk of lung cancer.

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Funding

This research has received competitive funding by the Instituto de Salud Carlos III, Ministry of Science and Innovation of Spain, grant number PI031248. This work was performed at the Ourense and Santiago de Compostela Hospital Complexes and also at the School of Medicine at the University of Santiago de Compostela.