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Abstract
Objectives: To explore the role of sociodemographic and lifestyle factors in the development of gastric cancer in a high-risk region of China.
Methods: In a case–control study, all newly diagnosed patients with gastric cancer were compared with healthy controls matched (1:1) by sex, age (±3 years), and place of residence during 2013–2017.
Results: A total of 622 gastric cancer and 622 healthy controls were included. Larger household size (>4 family members) appeared to decrease gastric cancer risk for Helicobacter pylori-negative ones (odd ratio = 0.43, 95% CI = 0.26–0.70). Similarly, longer refrigerator ownership was associated with a 67% decreased risk in H. pylori-negative group (95% CI = 0.15–0.77). Participants with a family history of gastric cancer had nearly fivefold higher risk (odd ratio = 4.88, 95% CI = 2.49–9.55). Smoking attributed to 83% increased risk (odd ratio = 1.83, 95% CI = 1.19–2.80). Tea consumption dramatically decreased risk in whole study population (odd ratio = 0.28, 95% CI = 0.17–0.45).
Conclusions: In summary, family history, smoking, H. pylori-related chronic atrophic gastritis, and H. pylori infection were positively associated with gastric cancer. Whereas, tea consumption and refrigerator use negatively associated with gastric cancer and could be promoted to reduce gastric cancer rate in high-risk populations, especially in the developing regions.
Acknowledgments
The authors appreciate all study participants and research investigators, students during the entire study period.
Disclosure Statement
The authors declare that they have no conflict of interest.
Ethical Standards Disclosure
This study was conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving human subjects/patients were approved by the Xianyou County Hospital and Fujian Medical University. Written informed consent was obtained from all subjects/patients at the study enrollment.
Additional information
Funding
Notes on contributors
Yulan Lin
The authors’ contributions to this study were as follows: study design: CW, WY, SG, and BL; data collection: CW, WY, SG, and BL; statistical analysis: YL; interpretation of results and manuscript writing: all authors. None of the authors had a personal or financial conflict of interest.
Chuancheng Wu
The authors’ contributions to this study were as follows: study design: CW, WY, SG, and BL; data collection: CW, WY, SG, and BL; statistical analysis: YL; interpretation of results and manuscript writing: all authors. None of the authors had a personal or financial conflict of interest.
Wei Yan
The authors’ contributions to this study were as follows: study design: CW, WY, SG, and BL; data collection: CW, WY, SG, and BL; statistical analysis: YL; interpretation of results and manuscript writing: all authors. None of the authors had a personal or financial conflict of interest.
Saixiong Guo
The authors’ contributions to this study were as follows: study design: CW, WY, SG, and BL; data collection: CW, WY, SG, and BL; statistical analysis: YL; interpretation of results and manuscript writing: all authors. None of the authors had a personal or financial conflict of interest.
Su Lin
The authors’ contributions to this study were as follows: study design: CW, WY, SG, and BL; data collection: CW, WY, SG, and BL; statistical analysis: YL; interpretation of results and manuscript writing: all authors. None of the authors had a personal or financial conflict of interest.
Baoying Liu
The authors’ contributions to this study were as follows: study design: CW, WY, SG, and BL; data collection: CW, WY, SG, and BL; statistical analysis: YL; interpretation of results and manuscript writing: all authors. None of the authors had a personal or financial conflict of interest.