Effect of Curcumin and Its Derivates on Gastric Cancer: Molecular Mechanisms

Abstract

Gastric carcinoma is one of the most prevalent malignancies and is associated with a high mortality. Chemotherapy is the principal therapeutic option in the treatment of gastric cancer, but its success rate is restricted by severe side effects and the prevalence of chemo-resistance. Curcumin is a polyphenolic compound derived from turmeric that has potent antioxidant, anti-inflammatory and anti-tumor effects. There is accumulating evidence that curcumin may prevent gastric cancer through regulation of oncogenic pathways. Furthermore some curcumin analogues and novel formulation of curcumin appear to have anti-tumor activity. The aim of this review was to give an overview of the therapeutic potential of curcumin and its derivatives against gastric cancer in preclinical and clinical studies.

Disclosure statement

The authors have no conflict of interest to disclose.

Author Contributions

All the authors listed above fulfilled the authorship criteria but some of them has more focus on the listed items. Afsane Bahrami conceived the idea. Afsane Bahrami and Gordon A.Ferns wrote the manuscript. All authors approved the final manuscript and submission.

Additional information

Funding

This study was supported by Birjand University of Medical Sciences (Code: 5109).