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Article

Association between Dietary Intake of Folate and the Risks of Multiple Cancers in Chinese Population: A Dose-Response Meta-Analysis of Observational Studies

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Pages 1644-1656 | Received 11 May 2020, Accepted 21 Aug 2020, Published online: 08 Sep 2020
 

Abstract

Background and objective

A lot of existing studies had revealed the associations between dietary folate intake and certain cancers, and generated inconsistent results. In addition, evidence on the association among Chinese population has not been systematically assessed. Therefore, we conducted a meta-analysis on this topic.

Methods

PubMed and Embase were searched up to March 20, 2020 for potential studies. Pooled relative risks (RR) and dose-response analysis were used to examine dietary folate intake and cancers risks among Chinese population.

Results

Seven cohort studies and 9 case-control studies that involved 561538 participants and 10073 cancer events were included. The summary RR of cancer events for the highest vs. lowest category was 0.73 (0.61, 0.88). Dose-response analysis revealed that those maintaining 250 μg daily intake of dietary folate had the lowest risk of cancers events among Chinese.

Conclusion

Our findings indicate the inverse association between dietary folate intake and risk of cancers events, the association is especially clear in women.

Disclosure statement

The Authors declare that they have no conflict of interest.

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