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Abstract
Lung cancer is one of the common types of malignant disorders and the most prevalent cause of cancer-related mortality in the world. Although a wide range of approaches has been examined, strategies in prevention and treatment of lung cancer are still inadequate. Studies show that Vitamin D (VitD) is involved in various biological pathways and has been associated with the etiopathogenesis of several diseases, like cancers. In Vitro and In Vivo experiments have disclosed that VitD plays immunomodulatory and anti-tumor functions. Several lines of evidence have indicated that VitD is involved in the inflammatory settings of the lung. Epidemiological studies have reported that sufficient levels of VitD might be critical in the prevention of lung cancer. Polymorphisms in the genes encoding the different molecules involved in the signaling of VitD might affect the lung cancer risk as well as the quality and quantity of responses to different treatments. In this review article, we intended to clarify the implications of VitD in the normal biology and physiology of the lung and discuss diverse line of evidence about the possible role of VitD in the prevention or treatment of lung cancer.
Disclosure Statement
No potential conflict of interest was reported by the authors.
Acknowledgments
None.
Authors’ Contributions
HZ and WZ: Conception, Design and Inviting co-Authors to Participate. WW, WH, SX, QC and YJ: Writing Original Manuscript Draft. HZ and WZ: Review and Editing of Manuscript Critically for Important Intellectual Content and Provided Comments and Feedback for the Scientific Contents of the Manuscript. All Authors: Final Approval of the Manuscript to Be Submitted to Nutrition and Cancer for Publication.