https://orcid.org/0000-0002-6697-5471
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Abstract
Oral cancer (OC) is a multifactorial disease caused by isolated or combined risk factors related to tobacco, alcohol consumption, and human papillomavirus infection. It is an aggressive pathology with a low five-year survival rate after surgery, chemotherapy, and/or radiotherapy, frequently associated with severe side effects. Drugs with the highest anti-tumor effect are obtained from natural products with diverse biological and molecular activities and potential chemopreventive and anticancer properties. This review summarizes the natural products reported to have the chemopreventive and anti-tumor potential for OC treatment, showing that several of these compounds are promising candidates as chemopreventive agents, and those with the highest anti-tumor potential induce apoptosis and inhibit proliferation and metastasis-related processes. For this reason, natural products have the potential to be important preventive and therapeutic options for OC in the future.
Acknowledgments
The author thanks the Unidad de Investigación Básica Oral (UIBO) members for their accompaniment and support.
Disclosure Statement
No potential conflict of interest was reported by the authors.
Contribution Statement
Andrés Cardona-Mendoza:
Conception the work
Design the work
Data acquisition
Data Analysis
Drafting the work
Draft review
Final approval
Geovanny Olivares-Niño
Data acquisition
Data Analysis
Drafting the work
David Díaz-Báez
Data acquisition
Data Analysis
Drafting the work
Gloria Inés Lafaurie
Data Analysis
Drafting the work
Draft review
Final approval
Sandra J Perdomo
Conception the work
Design the work
Data acquisition
Data Analysis
Drafting the work
Draft review
Final approval