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Abstract
Malnutrition is an important prognostic indicator of laryngeal squamous cell carcinoma. Retrospective study with head and neck cancer patients who underwent total laryngectomy. 243 patients of both sex were evaluated. The univariate analyses demonstrated an increased risk of death for the patients with greater weight loss, hypoalbuminemia, radiotherapy as an initial treatment, salvage surgery, and radical neck dissection. In a Multivariate Cox regression, older age (p = 0.03, 95% confidence interval [CI] 1.003–1.06, hazard ratio [HR] 1.029), Nutritional Risk Index ≤100 (p = 0.008, 95% CI 1.18–3.12, HR 1.921) and adjuvant radiotherapy (p = 0.029, 95% CI 0.31–3.12, HR 0.544) demonstrated prognostic significance in survival. Nutritional status is a modifiable variable and these findings highlight the need to adoption of simple nutritional assessment methods routinely during the treatment of head and neck cancer patients, in order to help improve prognosis after surgery.
Acknowledgments
The authors thank the National Cancer Institute Jose Alencar Gomes da Silva for providing the data for the research. The study received approval from the INCA research ethics committee (# 2165873).
Disclosure Statement
No potential conflict of interest was reported by the authors.
Statement of Authorship
Adriana Santos: 1. design, acquisition, analysis and interpretation of data; 2. drafting the article and critical revision of important intellectual content; 3. final approval of the version to be submitted; 4. agreement to be accountable for all aspects of the work.
Izabella Costa Santos: 1. analysis and interpretation of data; 2. drafting the article and critical revision of important intellectual content; 3. final approval of the version to be submitted; 4. agreement to be accountable for all aspects of the work.
Patrícia Fonseca dos Reis: 1. drafting the article and critical revision of important intellectual content; 2. final approval of the version to be submitted; 3. agreement to be accountable for all aspects of the work.
Viviane Dias Rodrigues: 1. drafting the article and critical revision of important intellectual content; 2. final approval of the version to be submitted; 3. agreement to be accountable for all aspects of the work.
Wilza Arantes Ferreira Peres: 1. design, analysis and interpretation of data; 2. drafting the article and critical revision of important intellectual content; 3. final approval of the version to be submitted; 4. agreement to be accountable for all aspects of the work.