GC-MS Profiling and Antineoplastic Activity of Pelargonium Inquinans Ait Leaves on Acute Leukaemia Cell Lines U937 and Jurkat

Abstract

We investigated the antineoplastic activities of extracts of Pelargonium inquinans leaves, a plant native to South Africa on acute leukemia cell lines, U937 and Jurkat and the inflammatory effect (nitric oxide and cyclo-oxygenase-2) on RAW 264.7 cells. The extracts of Pelargonium inquinans have significant cytotoxicity especially on U937 cells and pro-inflammatory release of nitric oxide on RAW 264.7 macrophages. The GC-MS study of the essential oil showed it had more than a hundred compounds. This study showed that Pelargonium inquinans have antineoplastic and anti-inflammatory activities which can be further explored in In Vivo studies.

Acknowledgments

The authors would like to extend their appreciation to Professor Maryna Van de Venter and Dr Trevor Koekemoer, Nelson Mandela University for their support.

Disclosure Statement

No potential conflict of interest was reported by the authors.

Authors Contribution

OI conceived the study, carried out the biochemical studies, participated in the GC-MS studies, performed the statistical analysis and drafted the manuscript. GO participated in the GC-MS studies, participated in the design of the study and the statistical analysis. GB participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.

Availability of Data and Materials

The datasets analyzed during the current study are available from the corresponding author on reasonable request.

Additional information

Funding

This project was funded by the Govan Mbeki Research and Development Center, South Africa.