![Sample our Health and Social Care journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5938/TOC-Subject-Sample-2021-Health-Social-Care.jpg"})
Abstract
Cervical cancer (CC) is a severe malignant tumor. Recently, more and more evidence has shown that abnormal expression of fatty acid synthase (FASN) occurs in varying tumors. Therefore, this investigation devoted to FASN in CC along with its upstream regulatory miRNA. Their expression levels were tested by qRT-PCR. Cell function experiments were undertaken to test tumor-related cell behaviors. Identification of their interplay was conducted by western blot and dual-luciferase methods. As analyzed, miR-497-5p was at low level in human CC cell lines, while FASN was overexpressed and demonstrated as a target of miR-497-5p. Cell function experiments demonstrated the targeting of miR-497-5p to FASN 3′-UTR, thus restraining CC development. To sum up, this investigation primarily revealed miR-497-5p/FASN axis in CC, by which potential CC biomarkers, could be developed. However, the mechanism of the axis was not determined in vivo, as one of the study limitations.
Disclosure statement
The authors declare no conflicts of interest.
Ethics Approval and Consent to Participate
Not applicable.
Consent for Publication
All authors consent to submit the manuscript for publication.
Availability of Data and Materials
The data used to support the findings of this study are included within the article. The data and materials in the current study are available from the corresponding author on reasonable request.
Authors’ Contributions
HZ and RW contributed to the study design. XT conducted the literature search. Jun L acquired the data. Jie L wrote the article. MW performed data analysis and drafted. HZ revised the article. All the authors gave the final approval of the version to be submitted.