Abstract
Purpose
To evaluate the prognostic value of pretreatment albumin-to-fibrinogen ratio (AFR) in colorectal cancer (CRC).
Methods
This retrospective study included 657 CRC patients who underwent surgical resection in 2012–2014. Kaplan-Meier survival curve and Cox proportional hazards model were used to determine independent predictors. Receiver operating characteristic curve analysis was used to assess and compare the ability of indicators to predict survival.
Results
The optimal cutoff value of AFR was 8.3. Compared with high AFR group, low AFR group had shorter progression-free survival (PFS) (65.32% vs 52.28%, p < 0.001) and overall survival (OS) (67.47% vs 56.14%, p = 0.001). In the stratified analysis of TNM stage, AFR had good prognostic discrimination for early- and advanced-stage patients. Multivariate analysis suggested that AFR was an independent prognostic factor of PFS [hazard ratio (HR) = 1.385, 95% confidence interval (CI) = 1.043–1.839, p = 0.024) and OS (HR = 1.342, 95% CI = 1.022–1.763, p = 0.034) for CRC patients. AFR had better prognostic prediction ability than other inflammation-related markers. The AFR-based nomograms had good predictive capabilities.
Conclusions
Pretreatment AFR is an independent prognostic factor for CRC patients undergoing surgical resection and is superior to other established inflammation-related markers.
Acknowledgments
The authors thank all patients and the medical staff who managed the patients in practice.
Author Contributions
JLG, HLX performed and designed this study. GHY, SZH, SYT, LSW provided clinico-pathological data and analyses. HLX wrote the manuscript. JLG and LSW edited the manuscript. All the authors reviewed the manuscript. Writing-original draft: HLX; Writing-review and editing: JLG, SYT, LSW.
Availability of Data and Materials
The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Disclosure Statement
No potential conflict of interest was reported by the authors.