The interaction between plant lectins and the small intestinal epithelium: A primary cause of intestinal disturbance

Summary

The literature concerning the effects of plant lectins on the small intestinal epithelium is reviewed. It appears that after oral intake, intact plant lectins can reach the small intestinal lumen. Their binding to the mucosal surface evokes an increased synthesis of glycoproteins and a degeneration of the intestinal epithelium. The epithelial alterations may result in hyperregenerative villus atrophy and endogenous nitrogen loss. These changes ultimately can lead to less efficient feed conversion, diminished growth, scouring, wasting and death. The possible significance of plant lectins in digestive disturbances in farm animals is suggested.

Notes

Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 1, P.O. Box 80.158, 3508 TD Utrecht, The Netherlands.

Former senior student Department of Veterinary Pathology.