Elimination of aminoglycoside antibiotics in milk following intramammary administration

Summary

The elemination in cow milk of aminoglycoside antibiotic residues (neomycin, dihydrostreptomycin, kanamycin and gentamicin) was studied after intramammary administration of eight drug formulations marketed in France. Quantitative residue analysis was performed by a cylinder plate method. The sensitivity was 0.15μg/ml for neomycin, dihydrostreptomycin, kanamycin and 0.025μg/ml for gentamicin. The mean elimination periods ranged between 4 and 13 milkings. Several ways of assessing withdrawal times are discussed.

Notes

Ministère de l'Agriculture, Centre National d'Etudes et Alimentaires, Laboratoire des Médicaments Vétérinaires, Javené ‐ 35133 Fougères, France.