Plasma levels of fenbendazole metabolites in buffalo and cattle after long‐term intraruminal administration

Summary

Plasma metabolite levels were measured in buffalo and cross‐bred cattle after daily intraruminal administration of fenbendazole at 0.5 mg/kg body weight. An equilibrium between the absorption of fenbendazole and disposition of its metabolites could be observed between days 3 to 6 and remained almost unchanged thereafter. The buffaloes had a lower uptake of the anthelmintic and lower plasma levels of its metabolites than in cattle. The findings were compared with those obtained after a single intraruminal therapeutic dose of fenbendazole.

Notes

Animal Disease Research Laboratory, National Dairy Development Board. Anand‐388 001, Gujarat, India.