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CASE REPORTS

Reversibility of Tamoxifen® Retinopathy—A Ten-Year Follow-Up

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Pages 214-221 | Accepted 26 Mar 2008, Published online: 08 Jul 2009
 

Abstract

High doses of the non-steroidal oral antiestrogen tamoxifen (60 mg/mCitation/day or more for at least 1 year) may cause decreased visual acuity due to retinal crystalline deposits and other ocular side-effects. A 56-year-old female patient suffering from pulmonary lymphangioleiomyomatosis (BML) with paraneoplastic estradiol production was presented with deterioration of visual acuity because of bilateral macular degeneration after an intake of 190–250 mg/day Tamoxpuren for five years. After discontinuing tamoxifen, ocular side-effects disappeared, perimetric and electrophysiological alterations almost normalized while visual acuity increased internal medical findings remained stable.

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