Surface modification of PLGA nanofibrous biocomposites using flavonoids for biomedical applications

Abstract

Rutin-containing poly(L-lactide-co-glycolide) (PLGA) nanofibrous biocomposites were prepared by electrospinning technique and antibacterial properties of the biocomposites were examined. Two types of bacterial strains, Staphylococcus aureus and Klebsiella pneumoniae were used in this test. The results showed that the rutin-containing PLGA nanofibrous biocomposites exhibited significant antibacterial effects against both the bacteria. Human nasopharyngeal epidermoid carcinoma (KB) epithelial cells were used to evaluate cytotoxicity. It was found that there was no cytotoxicity for the rutin-containing PLGA nanofibrous biocomposites.

Keywords:

• PLGA
• nanofiber
• antibacterial
• cytotoxicity
• rutin

Acknowledgments

This research was supported by the research grants of the Biotechnology Development Project (2009-0090907) and by the grant 2010-0011125 from the Ministry of Education, Science and Technology of Korea.