THE EFFECT OF LEPTIN ON THE VENTILATORY RESPONSETO HYPEROXIA

Groeben Harald □ Department of Anesthesiology and Critical Care Medicine, and Department of Environmental Health Sciences/Division of Physiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USACorrespondence[email protected]

Sascha Meier □ Department of Environmental Health Sciences/Division of Physiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

Robert H. Brown □ Department of Anesthesiology and Critical Care Medicine, Department of Medicine/Division of Pulmonary Medicine, and Department of Environmental Health Sciences/Division of Physiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

Christopher P. O'Donnell □ Department of Medicine/Division of Pulmonary Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

Mitzner Wayne □ Department of Environmental Health Sciences/Division of Physiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

Clarke G. Tankersley □ Department of Environmental Health Sciences/Division of Physiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

Abstract

□ Leptin-deficient mice show a blunted response to hypercapnia explained by central nervous system effects. The impact of leptin on peripheral chemoreceptor function is unclear. Therefore, 9 mutant (ob/ob) and 9 wild-type ( +/+ ) mice were exposed to room air or 100% oxygen and respiratory rate (RR) and tidal volume (Vt) were measured. Subsequently, ob/ob mice received either leptin or vehicle and measurements were repeated. Compared to baseline, for +/+ mice, RR decreased significantly by 9.4% ± 3.0% (means ± SD), whereas Vt remained unchanged. Transition from normoxia to hyperoxia did not change RR and Vt in untreated ob/ob mice, whereas after leptin treatment, RR and Vt decreased significantly. Leptin deficiency abolishes the response to hyperoxia, which is restored by leptin replacement. Thus, leptin seems to be influential for a competent peripheral chemoreceptor function.

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THE EFFECT OF LEPTIN ON THE VENTILATORY RESPONSETO HYPEROXIA

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THE EFFECT OF LEPTIN ON THE VENTILATORY RESPONSETO HYPEROXIA

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