INTRAPLEURAL LOW-MOLECULAR-WEIGHT UROKINASE OR TISSUE PLASMINOGEN ACTIVATOR VERSUS SINGLE-CHAIN UROKINASE IN TETRACYCLINE-INDUCED PLEURAL LOCULATION IN RABBITS

Steven Idell Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas, USACorrespondence[email protected]

Ali Azghani Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA; The University of Texas at Tyler, Tyler, Texas, USA

Shande Chen Department of Biostatistics, The University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA

Kathy Koenig Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA

Andrew Mazar Attenuon, LLC, San Diego, California, USA

Lalitha Kodandapani Attenuon, LLC, San Diego, California, USA

Khalil Bdeir Department of Pathology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA

Douglas Cines Department of Pathology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA

Irina Kulikovskaya Department of Pathology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA

Timothy Allen Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA

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Abstract

The authors compared the ability of a single dose of the proenzyme single-chain urokinase (scuPA), low-molecular-weight urokinase, tissue plasminogen activator (tPA), or a mutant site-inactive scuPA to resolve intrapleural loculations at 72 to 96 hours after tetracycline-induced pleural injury in rabbits. Both scuPA and tPA reversed loculations at 96 hours after injury P ≤ .001, whereas low-molecular-weight urokinase and the scuPA mutant were ineffective. scuPA and tPA generated inhibitor complexes, induced fibrinolytic activity, and quenched plasminogen activator-1 activity in pleural fluids. The authors conclude that scuPA reverses loculations as effectively as tPA at clinically applied intrapleural doses, whereas low-molecular-weight urokinase was ineffective.

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INTRAPLEURAL LOW-MOLECULAR-WEIGHT UROKINASE OR TISSUE PLASMINOGEN ACTIVATOR VERSUS SINGLE-CHAIN UROKINASE IN TETRACYCLINE-INDUCED PLEURAL LOCULATION IN RABBITS

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INTRAPLEURAL LOW-MOLECULAR-WEIGHT UROKINASE OR TISSUE PLASMINOGEN ACTIVATOR VERSUS SINGLE-CHAIN UROKINASE IN TETRACYCLINE-INDUCED PLEURAL LOCULATION IN RABBITS

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